Umbilical Cord–Derived Sources for Exosome Production
The most common source used in research and clinical applications is mesenchymal stem cells (MSCs). Numerous studies have also shown that umbilical cord blood mononuclear cells as well as umbilical cord blood plasma are valuable sources of exosomes.
Production and purification process
At Novacell, exosomes are isolated using ultrafiltration and ultracentrifugation technologies. They are then purified and stabilized through precise nanophysical and biochemical methods to preserve their quality and functional efficacy.
Performance and effectiveness
The mechanism of action is based on delivery of cargo to target cells, leading to modulation of signaling networks and gene expression. The effects of exosomes include:
- Anti‑inflammatory and immunomodulatory effects
- Pro‑repair activity and enhanced regeneration
- Anti‑apoptotic and anti‑fibrotic effects
- Organ‑specific effects, particularly in tissues such as the eye and joints
Advantages
This product is cell‑free, eliminating risks such as host immune reactions, cell entrapment, or unwanted cell proliferation.
Applications
- Wound healing and skin regeneration
- Treatment of dry eye conditions
- Joint repair and regeneration
- Use in medical and aesthetic formulations (e.g., mesotherapy and dermapen applications)
- Support of neural and muscular tissue regeneration
